TERA-print

Weekly Research Spotlight! Published in Advanced Materials, researchers at Northwestern University unveil a breakthrough platform that traverses the periodic table using phase-separating nanoreactors. By engineering polystyrene-based nanoscale reactors that induce precursor phase separation using a T-Series instrument, the team synthesized well-defined nanoparticles from 52 different metals, which is a dramatic leap beyond previous element-limited methods. This approach enables massive nanoparticle megalibraries with millions of unique compositions on a single chip, providing an unprecedented foundation for AI-driven materials discovery. This resulted in a versatile, high-throughput strategy that opens nearly limitless possibilities for next-generation catalysts, electronics, energy materials, and nanomedicine. https://lnkd.in/gDmcnRjs #Nanotechnology #MaterialsScience #AdvancedMaterials #Nanoparticles #HighThroughput #AIinScience #Catalysis #Nanomedicine #EnergyMaterials #NorthwesternUniveristy #TERAprint #TSeries

Weekly Research Spotlight! Exciting research in ACS Nano, an integrated computational–experimental framework has been developed to accelerate the discovery of antibacterial nanomedicines. By combining density functional theory (DFT) modeling, nano-QSAR toxicity predictions, and scanning probe block copolymer lithography using a T-Series instrument, researchers in China screened hundreds of alloy nanoparticles from the Materials Project database. They determined AuCu₃ nanoparticles showed strong peroxidase-like activity, low cytotoxicity, and potent antibacterial effects against E. coli and S. aureus. This work demonstrates how inverse screening, inspired by drug discovery, can speed up nanomedicine innovation and could guide the design of next-generation enzyme-mimicking therapies. https://lnkd.in/g7idheMW #Nanomedicine #Antibacterial #Nanozymes #MaterialsScience #Nanotechnology #DrugDiscovery #ComputationalBiology #TERAprint #TSeries

This Week's Research Spotlight A team of researchers at Northwestern University explore how mixed halide perovskites can be engineered across a continuum from heterostructures to solid solutions, offering powerful control over their structure and optoelectronic properties. Using a T-Series instrument, they systematically studied how halide ions mix and distribute within perovskite lattices, the team demonstrated new pathways to tailor bandgaps, stability, and charge transport, all key factors for solar cells, LEDs, and photodetectors. This work highlights the versatility of halide mixing not just as a tool for property tuning, but as a fundamental design strategy for creating highly functional, customizable perovskite materials. The insights pave the way for more stable, efficient, and tunable optoelectronic devices that bridge fundamental chemistry with real world applications. https://lnkd.in/g4DeawJH #MaterialsScience #Perovskite #Optoelectronics #SolarEnergy #Semiconductors #AdvancedMaterials #Nanotechnology #EnergyInnovation #NU #TSeries #TERAprint

Weekly Research Spotlight Alert! Researchers led by Adam Braunschweig and colleagues at the CUNY Advanced Science Research Center have developed a broad‑spectrum antiviral using synthetic carbohydrate receptors (SCRs) that block viral entry across diverse virus families. Researchers screened 57 candidate molecules, utilizing TERA-print's Elite instrument to pattern highly precise N-glycan microarrays, their team pinpointed four SCRs that successfully halted infection from several high-risk viruses including SARS‑CoV‑2, MERS, Ebola, Marburg, Nipah, Hendra, and SARS‑CoV‑1 in both cell cultures and animal models. Notably, a single dose of a lead compound dramatically improved survival in a SARS‑CoV‑2 mouse model, reducing mortality to just 10% compared to 100% in untreated controls. These SCRs target conserved viral N‑glycans, blocking viral attachment and fusion, demonstrating a novel, scalable mechanism with the potential to serve as the frontline response to emerging pandemics. https://lnkd.in/gAtmaGXP #AntiviralResearch #BroadSpectrumAntiviral #SyntheticCarbohydrates #Virology #Glycans #ResearchInnovation #PublicHealth #DrugDiscovery #TERAprint #Elite #CUNY

Weekly Research Spotlight! Scientists at Rice and Stanford University have adapted scanning probe block-copolymer lithography (SPBCL) to fabricate large arrays of gold nanoparticles on glass, overcoming key challenges in nanoparticle synthesis. Unlike traditional methods, colloidal synthesis or electron beam lithography, SPBCL combines precise positioning, compositional control, and high throughput fabrication in one versatile platform. The resulting ~100 nm gold nanoparticles exhibit diverse shapes and support strong plasmon resonances. Using dark-field microscopy alongside electron and pump-probe techniques, they correlated optical and mechanical properties at scale revealing that these SPBCL synthesized nanoparticles are highly crystalline, with plasmon oscillation and vibration lifetimes comparable to the best colloidal nanospheres. This work positions SPBCL as a powerful route to systematically screen optical properties of nanoparticles, paving the way for advanced applications in optics, sensing, and nanophotonics. https://lnkd.in/gbgKDUXH #Nanotechnology #Plasmonics #Nanoparticles #MaterialsScience #Nanophotonics #OpticalEngineering #ResearchInnovation #Sensing #TERAprint #TSeries

Weekly Research Spotlight! Unveiling a combinatorial synthesis and screening approach that rapidly explores the vast chemical space of mixed-halide perovskites, promising materials for solar cells and optoelectronics. By using Polymer Pen Lithography (PPL) via the T-Series instrument they created “megalibraries” containing thousands of unique compositions on a single chip. Coupling this with high-throughput screening, they identified key structural and optical trends, as well as optimal halide ratios for stability and performance. This method drastically accelerates the pace of perovskite discovery, offering a scalable path toward more efficient, durable, and tunable materials for next-generation energy and photonic devices. https://lnkd.in/gqkujyrX #MaterialsScience #Perovskite #SolarEnergy #Optoelectronics #HighThroughput #CombinatorialChemistry #EnergyInnovation #TERAprint #TSeries #Photovoltaics #NextGenMaterials

Weekly Research Spotlight! Researchers from Boston University and the University of Maryland have developed a massively parallel, cantilever-free atomic force microscopy (AFM) system that overcomes the long standing tradeoff between high resolution and limited imaging area. By replacing traditional cantilevered probe with over 1,000 rigid microprobes mounted on an E-Series instrument using a novel “distributed optical lever” to detect probe-sample contact. The team achieved sub-10 nm vertical precision and 100 nm lateral resolution across millimeter scale areas in a single scan. This scalable, high-throughput approach could revolutionize nanoscale imaging in fields like integrated circuit inspection, optical metasurface characterization, and biological tissue analysis, paving the way for rapid, detailed mapping of complex surfaces at unprecedented speed and scale. https://lnkd.in/g9CwiM4r #Nanotechnology #Microscopy #AtomicForceMicroscopy #AFM #MaterialsScience #TERAprint #ESeries #Nanofabrication #SurfaceAnalysis #HighResolutionImaging #Nanoscience #AdvancedManufacturing #Metrology

New Weekly Research Spotlight! Researchers have developed a powerful platform called Polymer Brush Hypersurface Photolithography, enabling the creation of highly customizable polymer brush microarrays with unprecedented control. By integrating a digital micromirror device, an air-free reaction chamber, and microfluidics, the E-Series instrument allows independent modulation of monomer composition and polymer height at micrometer resolution for each of over 750,000 individual “polymeric pixels.” Unlike traditional lithography, which requires photomasks, this method supports patterning of both random and block copolymer brushes through light-directed surface-initiated atom transfer radical polymerization (SI-ATRP). Critically, it also enables high throughput analysis of polymerization kinetics, accelerating material discovery and surface optimization. This versatile and scalable platform opens new avenues in fields such as smart coatings, tissue engineering, and surface chemistry by offering a generalizable tool for combinatorial photochemical patterning of complex soft materials. https://lnkd.in/gZa6gyNH #cellbiology #immunotherapy #ligandpatterning #syntheticbiology #nanobiotech #spatialbiology #biomaterials #TERAprint #ESeries #DMD #PolymerBrush

This edition of the Weekly Research Spotlight! The nanomaterial landscape is so vast that a high-throughput combinatorial approach is required to understand structure function relationships. To address this challenge, an approach for the synthesis and screening of megalibraries of unique nanoscale features (>10,000,000) with tailorable location, size, and composition has been developed. Polymer pen lithography, a parallel lithographic technique using the TERA-print T-Series, is combined with an ink spray-coating method to create pen arrays, where each pen has a different but deliberately chosen quantity and composition of ink. With this technique, gradients of Au-Cu bimetallic nanoparticles have been synthesized and then screened for activity by in situ Raman spectroscopy with respect to single-walled carbon nanotube (SWNT) growth. Au3Cu, a composition not previously known to catalyze SWNT growth, has been identified as the most active composition. https://lnkd.in/g2cv83Bc #materialsdiscovery #catalysis #nanotechnology #megalibraries #combinatorialchemistry #energymaterials #PPL #TERAprint #TSeries #AdvancedMaterials

Our Next Installment of the Weekly Research Spotlight: Researchers in New York developed a powerful method for fabricating glycan microarrays using maskless photochemical printing, eliminating the need for physical masks. Using a combination of the ESeries instrument and fluidics, they achieved sub-10 µm resolution in patterning NHS-activated glass surfaces with a diverse set of carbohydrate ligands. This innovation enables the rapid, high-density production of over 500 unique glycan spots per mm² with precise spatial control over glycan identity and density. The resulting microarrays are ideal for high-throughput screening of glycan–protein interactions, immune response profiling, and biomarker discovery. This scalable and flexible approach marks a significant advance for synthetic biology, glycomics, and biomedical diagnostics. https://lnkd.in/gguiSKYR #glycan #bioprinting #DMD #microarrays #biotech #highthroughput #syntheticbiology #masklesslithography #TERAprint #ESeries